Watching their cholesterol by Karla Harby
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 Alliance scientists have their eyes on cholesterol, all right, but not just for their health. They're set to make discoveries about how cells communicate and take some of the first steps toward nanodevices based on living cells.

Cholesterol. The word itself evokes images of arteries narrowed by atherosclerotic plaque, the gunk that sticks to vessels and impedes the passage of blood the way a kink in a garden hose slows the flow of water. Or perhaps we think of cholesterol as something our favorite foods—ice cream, two-crust pies, steaks, French fries—are rich in, a culinary spoiler that makes us choose the fish yet again. (Hold the Béarnaise, please.)

But the drumbeat of public health messages about the hazards of too much dietary cholesterol obscures a more complex reality, namely that cholesterol is essential to animal life. In fact, much of the cholesterol in us is manufactured by our own bodies, not obtained from our foods. It serves as a precursor to the sex hormones estradiol and testosterone and to vitamin D, which is necessary for the formation of bone. Cholesterol is also needed to produce the bile acids that digest fats. Cholesterol is only dangerous when the body's regulation of it goes awry, owing to genetic or environmental causes.

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Membrane in a gel state with straightened chains. The green chains are hydrocarbons, the blue elements are cholesterol, and the red spheres are the head-group atoms of the lipids. The cholesterol is removed to show the lipid chains more clearly in the visualization on the right.


For a group of scientists using Alliance resources, the most fascinating aspect of cholesterol is its role in regulating membrane fluidity in animal cells. This group—Eric Jakobsson of the Beckman Institute for Advanced Science and Technology, Urbana, Illinois; H. Larry Scott, chair of biological, chemical, and physical science at the Illinois Institute of Technology in Chicago; and R. Jay Mashl and See-Wing Chiu, also of Beckman, the University of Illinois at Urbana-Champaign, and NCSA—use the prototype 64-processor, Itanium-based Linux cluster at NCSA to perform computational studies that could lead to a deeper understanding of how cells communicate with each other. What's more, their work may contribute to the development of nanodevices based on living cells.


Access Online | Posted 10-9-2001

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